Weight-loss peptide research & sourcing guide

Understand weight-loss peptides. Then source them with confidence.

Mechanism-level profiles and trial-data write-ups for GLP-1, dual, and triple agonist research compounds, plus price comparisons across two research suppliers, Core Power Peptides and American Peptides.

Supplier claims labeled as claims
Price per mg on every listing
Date shown on every price
Sourced trial data, not hype
Most compared

Tirzepatide: the compound newer drugs are measured against

Tirzepatide is the dual-agonist reference compound in this class. Newer multi-receptor agonists such as retatrutide are compared with it in the trial literature. Research-use listings are available at Core Power Peptides and American Peptides; our head-to-head article covers the evidence.

  • Dual GIP/GLP-1 receptor agonist, the reference compound for newer multi-receptor drugs
  • SURMOUNT-5: -20.2% vs -13.7% for semaglutide at 72 weeks (open-label, Lilly-funded)
  • Approved prescription tirzepatide exists; research-grade material is not the approved product
  • Research-use-only listing: the supplier states purity and testing, which we have not verified

Disclosure: this is a paid affiliate relationship. Links marked “Shop”, “Check price” or “View” go to Core Power Peptides or American Peptides, our research-peptide supplier partners. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them. Products are sold for laboratory research only, not for human or veterinary use.

$320$416

50 mg vial · $6.40/mg · lyophilized powder
Struck-through price is the supplier’s own pre-sale listing. Checked Oct 20, 2026.

Category
GIP / GLP-1 Dual Agonist
Sequence length
39 amino acids
Research status
Approved analog exists
Best for
The dual-agonist most researchers reach for first
Check current price

How sourcing works

Research the compound

Review the mechanism, agonist class, and current research status for the peptide you are interested in.

Compare pathway and price

Weigh receptor pathway against current pricing across the GLP-1, dual, and triple agonist compounds we track.

Check the supplier evidence

Before trusting any listing, ask for a lot-specific certificate of analysis from a named outside lab. Our COA guide explains what to look for.

Weight-loss peptide compounds

14 compounds studied across GLP-1, dual, and triple agonist pathways, plus growth-hormone and NNMT-adjacent research chemicals. Compounds currently in stock link straight to pricing.

GLP-1 compound pricing, compared

Current Core Power Peptides and American Peptides pricing for every incretin-pathway compound we track, so you can weigh mechanism against cost before choosing one to research.

CompoundPathwayBest forVialCore Power Peptides$/mgAmerican Peptides
TirzepatideEditor's pick
GIP / GLP-1 Dual AgonistThe dual-agonist most researchers reach for first50 mg$320$416$6.40/mgShopfrom $10010mg · $10.00/mgView
Semaglutide
GLP-1 Receptor AgonistSingle-pathway GLP-1 research; the reference comparator for newer agonists10 mg$75$7.50/mgShopfrom $16020 mg · $8.00/mgView
Cagrilintide
Long-Acting Amylin AnalogAmylin-pathway research, commonly paired with semaglutide10 mg$220$286$22.00/mgShopfrom $17010 mg · $17.00/mgView
Mazdutide
GLP-1 / Glucagon Dual AgonistGlucagon-pathway research as an alternative to GIP-based dual agonists10 mg$80$104$8.00/mgShop—Not listed
Retatrutide
GIP / GLP-1 / Glucagon Triple AgonistThree-receptor (GIP, GLP-1, glucagon) mechanism research—Not stocked—Unavailablefrom $10510 mg · $10.50/mgView
Tesofensine
Triple Monoamine Reuptake InhibitorNon-incretin appetite-pathway research80 mg$109$1.36/mgShop—Not listed
Liraglutide
GLP-1 Receptor AgonistA baseline GLP-1 comparator for newer incretin compounds—Not stocked—Unavailable—Not listed
Orforglipron
Oral Non-Peptide GLP-1 AgonistOral, non-peptide GLP-1 pharmacology comparisons—Not stocked—Unavailable—Not listed
Survodutide
GLP-1 / Glucagon Dual AgonistComparing GLP-1/glucagon dual agonism with three-receptor compounds—Not stocked—Unavailable—Not listed

Prices checked Oct 20, 2026 (Core Power Peptides) and Oct 20, 2026 (American Peptides; cheapest in-stock size shown, other sizes on each compound page). Vial sizes differ between suppliers, so compare $/mg rather than headline price. $/mg is the listed price divided by vial size, so compounds are comparable per milligram. Struck-through figures are the supplier’s own pre-sale listings.

Browse the full American Peptides catalog and prices

Supplier-issued code PEPTIDE101116 can be entered at checkout; confirm the current discount on their site.

Sold for laboratory research only, not for human or veterinary use. For purchasers aged 21 and over. #ResearchUseOnly

Disclosure: this is a paid affiliate relationship. Links marked “Shop”, “Check price” or “View” go to Core Power Peptides or American Peptides, our research-peptide supplier partners. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them. Products are sold for laboratory research only, not for human or veterinary use.

One receptor, two, or three: how the agonist classes differ

Each additional receptor pathway changes what researchers are studying, not just how strong the effect is.

Retatrutide

Triple agonist

Adds glucagon-receptor activation on top of GIP and GLP-1 signaling. The most mechanistically aggressive compound in this class, currently in late-stage trials.

3 of 3 receptor pathways

Semaglutide

GLP-1 only

Single-pathway incretin agonism. The reference point this entire research field is compared against.

Tirzepatide

GIP / GLP-1 dual

Combines two incretin pathways in one molecule, associated with larger mean reductions than GLP-1 alone.

What proper sourcing looks like

These are the checks we use to compare suppliers. Core Power Peptides and American Peptides both state that they provide certificates of analysis and third-party testing. We report those statements as the suppliers’ own claims, and we have not independently verified them.

Certificate of analysis

Every batch should ship with a COA verifying purity and identity through HPLC or mass spectrometry, not a generic template.

Independent third-party testing

In-house testing alone is not enough. Look for sourcing that is verified by a lab outside the manufacturer.

Cold-chain handling

Lyophilized peptides tolerate brief room-temperature shipping, but need refrigerated or frozen storage for long-term stability.

Research-use labeling

A "research use only" label means laboratory work. The FDA has warned sellers who marketed such products for human use, so the label is not a quality signal.

Batch traceability

Lot numbers printed on the vial should trace back to a specific, dated certificate of analysis.

Latest research

All articles

Frequently asked questions

Research peptides sold for laboratory use sit in a regulatory gray area in most jurisdictions. Some compounds discussed here, including semaglutide and tirzepatide, also exist as FDA-approved prescription drugs sold only through pharmacies. Nothing on this site is intended for human use, self-administration, or as medical advice.

Disclosure: this is a paid affiliate relationship. Links marked “Shop”, “Check price” or “View” go to Core Power Peptides or American Peptides, our research-peptide supplier partners. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them. Products are sold for laboratory research only, not for human or veterinary use.

Compare supplier prices before you decide

Every compound on this site can be checked against current Core Power Peptides and American Peptides pricing, with price per milligram and the date each price was checked.

Shop Core Power Peptides

Disclosure: this is a paid affiliate relationship. Links marked “Shop”, “Check price” or “View” go to Core Power Peptides or American Peptides, our research-peptide supplier partners. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them. Products are sold for laboratory research only, not for human or veterinary use.