Understand weight-loss peptides. Then source them with confidence.
Mechanism-level profiles and trial-data write-ups for GLP-1, dual, and triple agonist research compounds, plus price comparisons across two research suppliers, Core Power Peptides and American Peptides.
Tirzepatide: the compound newer drugs are measured against
Tirzepatide is the dual-agonist reference compound in this class. Newer multi-receptor agonists such as retatrutide are compared with it in the trial literature. Research-use listings are available at Core Power Peptides and American Peptides; our head-to-head article covers the evidence.
- Dual GIP/GLP-1 receptor agonist, the reference compound for newer multi-receptor drugs
- SURMOUNT-5: -20.2% vs -13.7% for semaglutide at 72 weeks (open-label, Lilly-funded)
- Approved prescription tirzepatide exists; research-grade material is not the approved product
- Research-use-only listing: the supplier states purity and testing, which we have not verified
Disclosure: this is a paid affiliate relationship. Links marked “Shop”, “Check price” or “View” go to Core Power Peptides or American Peptides, our research-peptide supplier partners. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them. Products are sold for laboratory research only, not for human or veterinary use.
50 mg vial · $6.40/mg · lyophilized powder
Struck-through price is the supplier’s own pre-sale listing. Checked Oct 20, 2026.
- Category
- GIP / GLP-1 Dual Agonist
- Sequence length
- 39 amino acids
- Research status
- Approved analog exists
- Best for
- The dual-agonist most researchers reach for first
How sourcing works
Research the compound
Review the mechanism, agonist class, and current research status for the peptide you are interested in.
Compare pathway and price
Weigh receptor pathway against current pricing across the GLP-1, dual, and triple agonist compounds we track.
Check the supplier evidence
Before trusting any listing, ask for a lot-specific certificate of analysis from a named outside lab. Our COA guide explains what to look for.
Weight-loss peptide compounds
14 compounds studied across GLP-1, dual, and triple agonist pathways, plus growth-hormone and NNMT-adjacent research chemicals. Compounds currently in stock link straight to pricing.
Tesofensine
Triple Monoamine Reuptake Inhibitor
A small-molecule triple monoamine reuptake inhibitor studied for appetite suppression through a central nervous system pathway entirely separate from incretin receptor agonism, often researched alongside GLP-1 compounds as a mechanistically distinct comparator.
GLP-1 compound pricing, compared
Current Core Power Peptides and American Peptides pricing for every incretin-pathway compound we track, so you can weigh mechanism against cost before choosing one to research.
| Compound | Pathway | Best for | Vial | Core Power Peptides | $/mg | American Peptides | ||
|---|---|---|---|---|---|---|---|---|
TirzepatideEditor's pick | GIP / GLP-1 Dual Agonist | The dual-agonist most researchers reach for first | 50 mg | $320$416 | $6.40/mg | Shop | from $10010mg · $10.00/mg | View |
Semaglutide | GLP-1 Receptor Agonist | Single-pathway GLP-1 research; the reference comparator for newer agonists | 10 mg | $75 | $7.50/mg | Shop | from $16020 mg · $8.00/mg | View |
Cagrilintide | Long-Acting Amylin Analog | Amylin-pathway research, commonly paired with semaglutide | 10 mg | $220$286 | $22.00/mg | Shop | from $17010 mg · $17.00/mg | View |
Mazdutide | GLP-1 / Glucagon Dual Agonist | Glucagon-pathway research as an alternative to GIP-based dual agonists | 10 mg | $80$104 | $8.00/mg | Shop | — | Not listed |
Retatrutide | GIP / GLP-1 / Glucagon Triple Agonist | Three-receptor (GIP, GLP-1, glucagon) mechanism research | — | Not stocked | — | Unavailable | from $10510 mg · $10.50/mg | View |
Tesofensine | Triple Monoamine Reuptake Inhibitor | Non-incretin appetite-pathway research | 80 mg | $109 | $1.36/mg | Shop | — | Not listed |
Liraglutide | GLP-1 Receptor Agonist | A baseline GLP-1 comparator for newer incretin compounds | — | Not stocked | — | Unavailable | — | Not listed |
Orforglipron | Oral Non-Peptide GLP-1 Agonist | Oral, non-peptide GLP-1 pharmacology comparisons | — | Not stocked | — | Unavailable | — | Not listed |
Survodutide | GLP-1 / Glucagon Dual Agonist | Comparing GLP-1/glucagon dual agonism with three-receptor compounds | — | Not stocked | — | Unavailable | — | Not listed |
Prices checked Oct 20, 2026 (Core Power Peptides) and Oct 20, 2026 (American Peptides; cheapest in-stock size shown, other sizes on each compound page). Vial sizes differ between suppliers, so compare $/mg rather than headline price. $/mg is the listed price divided by vial size, so compounds are comparable per milligram. Struck-through figures are the supplier’s own pre-sale listings.
Browse the full American Peptides catalog and prices
Supplier-issued code PEPTIDE101116 can be entered at checkout; confirm the current discount on their site.
Sold for laboratory research only, not for human or veterinary use. For purchasers aged 21 and over. #ResearchUseOnly
Disclosure: this is a paid affiliate relationship. Links marked “Shop”, “Check price” or “View” go to Core Power Peptides or American Peptides, our research-peptide supplier partners. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them. Products are sold for laboratory research only, not for human or veterinary use.
One receptor, two, or three: how the agonist classes differ
Each additional receptor pathway changes what researchers are studying, not just how strong the effect is.
Triple agonist
Adds glucagon-receptor activation on top of GIP and GLP-1 signaling. The most mechanistically aggressive compound in this class, currently in late-stage trials.
3 of 3 receptor pathways
GLP-1 only
Single-pathway incretin agonism. The reference point this entire research field is compared against.
GIP / GLP-1 dual
Combines two incretin pathways in one molecule, associated with larger mean reductions than GLP-1 alone.
What proper sourcing looks like
These are the checks we use to compare suppliers. Core Power Peptides and American Peptides both state that they provide certificates of analysis and third-party testing. We report those statements as the suppliers’ own claims, and we have not independently verified them.
Certificate of analysis
Every batch should ship with a COA verifying purity and identity through HPLC or mass spectrometry, not a generic template.
Independent third-party testing
In-house testing alone is not enough. Look for sourcing that is verified by a lab outside the manufacturer.
Cold-chain handling
Lyophilized peptides tolerate brief room-temperature shipping, but need refrigerated or frozen storage for long-term stability.
Research-use labeling
A "research use only" label means laboratory work. The FDA has warned sellers who marketed such products for human use, so the label is not a quality signal.
Batch traceability
Lot numbers printed on the vial should trace back to a specific, dated certificate of analysis.
Latest research
All articles
Pipeline & RegulationRetatrutide pricing: why there is no official price yetRetatrutide has no official price because no regulator has approved it. Lilly plans to file in Q1 2027. Here is what listings cost and what they leave out.ComparisonsTirzepatide vs retatrutide: what the trials show so farNo trial has compared tirzepatide with retatrutide yet. Lilly's head-to-head is due soon. Here is what the separate trials show and why they differ.Clinical DataMazdutide: GLP-1/glucagon dual-agonist trial resultsIn GLORY-1, mazdutide 6 mg produced a 14.0% mean weight loss at 48 weeks in Chinese adults. Here is the full trial record and where regulatory status stands.Frequently asked questions
Research peptides sold for laboratory use sit in a regulatory gray area in most jurisdictions. Some compounds discussed here, including semaglutide and tirzepatide, also exist as FDA-approved prescription drugs sold only through pharmacies. Nothing on this site is intended for human use, self-administration, or as medical advice.
It means the compound is sold for laboratory research, not for consumption. It has not been evaluated by the FDA for safety or effectiveness in humans through this sourcing channel, even if an approved analog exists elsewhere.
Each added receptor pathway (GIP, then glucagon) changes the biology being studied, not just the strength of the effect. See the mechanism comparison above for a breakdown by compound.
Lyophilized (freeze-dried) peptides are generally more stable than peptides in solution, which is why they ship as powder. Suppliers typically recommend cold, dark, dry storage; always follow the storage terms printed on the certificate of analysis or product label. This site does not give preparation or handling protocols.
No. This site is an independent research and comparison resource. We link out to Core Power Peptides and American Peptides, two research-peptide suppliers whose published quality claims we summarize but have not independently verified, and we may earn a commission on purchases made through those links at no extra cost to you. See our affiliate disclosure below.
Import regulations for research chemicals vary widely by country and change often. Check your local laws before placing an order from any source.
A peptide is a short chain of amino acids, like semaglutide or retatrutide, and generally cannot survive digestion, which is why peptide-class compounds are typically injectable. A small-molecule agonist, like orforglipron or 5-Amino-1MQ, reaches the same or a related receptor through a chemically different, non-peptide structure that can often be taken orally.
Approval status reflects how far a specific formulation has moved through regulatory review for human prescription use, not how much research exists on the underlying receptor pathway. A compound can be well studied in research settings while still sitting in preclinical or clinical-trial status, and an approved analog existing elsewhere does not change the research-only sourcing channel discussed on this site.
It confirms that a lab independent of the manufacturer, not the seller grading its own product, ran purity and identity testing (typically HPLC for purity and mass spectrometry for molecular identity) on that specific batch. In-house-only testing is not equivalent, since it carries no independent check on the result.
The compound name is just a label for a specific molecule; the receptor pathway is what determines the biology being studied. Two compounds with very different names can share a mechanism, and two compounds that sound similar can target entirely different receptors, which is why this site organizes profiles by mechanism class (GLP-1, dual agonist, triple agonist, and so on) rather than alphabetically.
Disclosure: this is a paid affiliate relationship. Links marked “Shop”, “Check price” or “View” go to Core Power Peptides or American Peptides, our research-peptide supplier partners. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them. Products are sold for laboratory research only, not for human or veterinary use.
Compare supplier prices before you decide
Every compound on this site can be checked against current Core Power Peptides and American Peptides pricing, with price per milligram and the date each price was checked.
Shop Core Power PeptidesDisclosure: this is a paid affiliate relationship. Links marked “Shop”, “Check price” or “View” go to Core Power Peptides or American Peptides, our research-peptide supplier partners. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them. Products are sold for laboratory research only, not for human or veterinary use.