GLP-1 / Glucagon Dual Agonist
Survodutide
A dual agonist pairing GLP-1 with glucagon receptor activity rather than GIP, studied as a mechanistically distinct alternative to tirzepatide-style incretin dual agonism.
Still in trials and not yet available through research-peptide suppliers. Mazdutide is the closest GLP-1/glucagon dual agonist in stock.
Mechanism
Combines GLP-1 receptor activation with direct glucagon receptor agonism, aiming to add the energy-expenditure signal associated with glucagon without waiting for a third receptor pathway. Researchers are comparing this two-receptor route against retatrutide's three-receptor approach to isolate how much of the effect glucagon activity contributes on its own.
Research focus
- Category
- GLP-1 / Glucagon Dual Agonist
- Sequence length
- 29 amino acids
- Research status
- In clinical trials
- Best for
- Comparing GLP-1/glucagon dual agonism with three-receptor compounds
Related compounds
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